Tokyo in the near future. A young man, Senri NOUNAI, joins a giant pharmaceutical company, RUOWA, to cure his bigger sister, Mari, of an incurable disease. There, he takes RUOWA METAL, a drug that turns muscle into metal, and suffers a side effect of turning brain cells into sand. He then kills people suffering from the same side effect himself. Today is his brother's wedding. He is afraid that his work will be exposed.